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A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 381-387 doi: 10.1007/s11684-012-0229-z

摘要：

Application of volatile anesthetics greatly alters modern medicine. There are obvious advantages of volatile anesthetics such as strong anesthetic potency, rapid onset and elimination through respiration system. Isoflurane is one of the most widely used volatile anesthetics in clinic. Emulsified isoflurane, the emulsion of isoflurane, is a novel intravenous general anesthetic. With the development of emulsified isoflurane in the past fifteen years, its utility has spread from intravenous general anesthesia to various fields including regional anesthesia, organ protection, as well as anesthetic pharmacological study. In this review, we will summarize literatures of emulsified isoflurane about its history, clinical application and future potential utility in the above mentioned fields.

关键词： emulsified isoflurane (EI)     general anesthesia     regional anesthesia     organ protection     anesthetic pharmacological study    

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Comparative cost analysis of three different anesthesia methods in gynecological laparoscopic surgery

null

《医学前沿（英文）》 2012年 第6卷 第3期   页码 311-316 doi: 10.1007/s11684-012-0205-7

摘要：

In the current study, we assessed and evaluated the costs and benefits of three popular methods of general anesthesia practiced in our department for gynecological laparoscopic surgery in recent years. Sixty adult female patients who underwent elective gynecological laparoscopic surgery under general anesthesia were randomly divided into three groups: group V, group I and group C. In group V, anesthesia was induced intravenously with midazolam, remifentanil, propofol and vecuronium, and maintained with continuous infusion of propofol and remifentanil. In group I, anesthesia was intravenously induced with midazolam, fentanyl, propofol and vecuronium, and maintained with inhaled isoflurane and intravenous bonus of fentanyl. In group C, anesthesia was induced as in group I, but maintained with isoflurane inhalation combined with propofol-remifentanil infusion. All patients received vecuronium for muscle relaxation. Perioperative incidences of complications and total anesthesia costs for patients in all groups were recorded. In addition, postoperative satisfaction of the patients was also noted, and similar outcomes of the satisfaction were reported in all 60 patients. Although there was no statistical significance among groups, the incidence of postoperative nausea and vomiting were higher in group C, and the rates of shivering and the needs for analgesics were higher in group V. Anesthesia costs in group I were the lowest. Therefore, it is concluded that the costs of anesthesia induced with midazolam, fentanyl, propofol, vecuronium, and maintained with isoflurane, fentanyl and vecuronium are cheapest, and there is no significant difference in patients’ satisfaction and safety among the three above-mentioned methods of anesthesia in our department.

关键词： general anesthesia     economics     cost    

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Effects of intracerebroventricular NMDA and non-NMDA receptor agonists or antagonists on general anesthesia

XU Aijun, TIAN Yuke, DUAN Shiming

《医学前沿（英文）》 2007年 第1卷 第2期   页码 207-210 doi: 10.1007/s11684-007-0039-x

摘要： The effects of intracerebroventricular (icv) agonists and antagonists of -methyl--aspartate (NMDA) and alpha-amino-3-hydroxy 5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the general anesthesia of propofol were studied. A total of 144 Kunming mice, male and female with body mass of (22?3) g, were used. Part One of the Experiment: a total of 104 Kunming mice, male and female, were randomly divided into 13 groups. Intracerebroventricular artificial cerebral fluid (aCSF) or different doses of NMDA, AMPA, MK-801 or NBQX was injected immediately after intravenously administered propofol 25 mg/kg and the recovery time following the loss of righting reflex (LORR) was recorded. Part Two of the Experiment: a total of 40 Kunming female mice were divided randomly into 5 groups and injected with icv aCSF or NMDA, AMPA, MK-801 or NBQX after intraperitoneally administered propofol 50 mg/kg. The pain threshold of the mice was then investigated by hot-plate test (HPPT). NMDA (0.05 or 0.075?g, icv) or AMPA (0.05 ?g, icv) exhibited no effects on the LORR, but NMDA (0.1 μg, icv) or AMPA (0.075 or 0.1 ?g, icv) prolonged the LORR significantly compared with the aCSF group (<0.05, <0.01). The LORR of the 2 μg MK-801 group had no changes, while those of the 4 or 8 μg MK-801 groups were prolonged significantly. The LORR of the 0.5, 2 or 4 μg NBQX groups were all prolonged significantly. NMDA 0.05 ?g or AMPA 0.05 ?g decreased the pain threshold slightly but did not differ in effect compared with the aCSF group; 2 μg MK-801 or 0.5 μg NBQX both increased the pain threshold significantly. Our results indicate that propofol produces general anesthesia partly through an interaction with brain NMDA and AMPA receptors in mice.
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民用支线飞机发展浅析

陈一坚

《中国工程科学》 2001年 第3卷 第2期   页码 16-20

摘要：

高科技、高投入、高风险、长周期的航空产品是一个国家工业水平和经济发达程度的重要标志之一。由于种种历史原因，我国民用航空产业发展相对缓慢。在西部大开发方针指引下，充分发挥陕西航空工业的优势，集中全行业资源和人才，发挥"哑铃型"研制模式，两头集中在陕西，并组成符合市场经济规律的股份公司，有利于民用支线飞机尽早提供给用户，成为21世纪初中国航空人应肩负的历史使命。文章浅析了如何发展支线飞机，以引起各方重视。

关键词： 民用支线飞机     涡扇型支线飞机     人公里数     支线运输网    

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endotracheal tube with or without epidural lidocaine reduces isoflurane requirement during general anesthesia

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《医学前沿（英文）》 2012年 第6卷 第3期   页码 302-306 doi: 10.1007/s11684-012-0194-6

摘要：

This study was designed to evaluate the effect of tracheal topical anesthesia using EMLA? Cream (EC) coated on the endotracheal tube (ETT) with or without epidural anesthesia (EA) on isoflurane requirement during general anesthesia (GA) and investigate whether EC coated on the ETT with EA was associated with the additive effect compared with the effect when each anesthetic was administered independently. The prospective randomized, double-blinded, and controlled study included 60 ASA I–II patients scheduled for upper abdominal surgery requiring GA. Patients were randomly assigned to one of the following groups: group 1 received GA, group 2 received EC+ GA, group 3 received GA+ EA, and group 4 received EC+ GA+ EA. Isoflurane was administered at the required concentrations to maintain the mean arterial pressure at a level not exceeding 20% of preoperative values. The percentage mean expired concentration (%MEC) was used in calculating the isoflurane requirement. Emergence agitation, postoperative sore throat, and hoarseness were recorded. Groups 2, 3, and 4 exhibited a significant reduction on isoflurane requirement compared with group 1 (P<0.05). The isoflurane requirement evaluated by %MEC decreased by 12%, 38%, and 50% in groups 2, 3, and 4, respectively. The incidence of emergence agitation was significantly lower in groups 2 and 4 than those in groups 1 and 3 (P<0.05). Tracheal topical anesthesia using EC coated on ETT with or without EA reduced the isoflurane requirement during GA, indicating that EC combined with EA exhibited an additive effect on the requirement of general anesthetic.

关键词： EMLA? Cream     epidural anesthesia     general anesthesia     isoflurane     lidocaine    

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Evaluation of ecosystem health for regional development in the southwestern Beijing, China

LIU Xuehua, ZHANG Shuang, XU Haoyang, SHAO Xiaoming

《环境科学与工程前沿（英文）》 2008年 第2卷 第3期   页码 311-317 doi: 10.1007/s11783-008-0047-3

摘要： Ecosystem health assessment is one of the most important issues in regional ecological quality and safety studies. It also has a great significance to ecological conservation and regional development. This study focused on assessing the health status of forest, agriculture and urban ecosystems in the southwestern Beijing, China, including the Fangshan and Fengtai Districts. Based on field surveys and data collection, an assessment index system containing the vigor, organization and resilience factors was developed to measure the ecosystem health. Each index was scored from 1 to 5, representing five levels that contribute to the whole ecosystem health. The analytic hierarchy process (AHP) method was used to measure the weights of each index and three factors, and thus an overall score for a certain ecosystem was calculated. The results show that the forest ecosystem in the Fangshan District had higher health value than the Fengtai District, while the urban ecosystem had a slightly lower value in the Fangshan District than the Fengtai District. Both districts show lower resilience values in forest and urban ecosystems. Maintaining the ecosystem health will definitely benefit the long-term development of two districts. This study suggested that an approach for assessing the regional ecosystem health could be further developed to address spatial and synergy relationships between ecosystems and the three health factors.

关键词： hierarchy process     regional ecosystem     synergy     agriculture     resilience    

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Understand the local and regional contributions on air pollution from the view of human health impacts

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1382-2

摘要：

• PM2.5-related deaths were estimated to be 227 thousand in BTH & surrounding regions.

关键词： PM2.5     Regional transport     Local emissions     Health impact     Environmental inequality    

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using the Berlin Questionnaire to detect potential high risk of adverse respiratory events in post anesthesia

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 189-195 doi: 10.1007/s11684-017-0533-8

摘要：

Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.

关键词： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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Cutting CO emissions through demand side regulation: Implications from multi-regional input–output linear

《工程管理前沿（英文）》   页码 452-461 doi: 10.1007/s42524-022-0209-1

摘要： This study combines multi-regional input–output (MRIO) model with linear programming (LP) model to explore economic structure adjustment strategies for the reduction of carbon dioxide (CO2) emissions. A particular feature of this study is the identification of the optimal regulation sequence of final products in various regions to reduce CO2 emissions with the minimum loss in gross domestic product (GDP). By using China’s MRIO tables 2017 with 28 regions and 42 economic sectors, results show that reduction in final demand leads to simultaneous reductions in GDP and CO2 emissions. Nevertheless, certain demand side regulation strategy can be adopted to lower CO2 emissions at the smallest loss of economic growth. Several key final products, such as metallurgy, nonmetal, metal, and chemical products, should first be regulated to reduce CO2 emissions at the minimum loss in GDP. Most of these key products concentrate in the coastal developed regions in China. The proposed MRIO–LP model considers the inter-relationship among various sectors and regions, and can aid policy makers in designing effective policy for industrial structure adjustment at the regional level to achieve the national environmental and economic targets.

关键词： CO2 emissions     demand side regulation     multi-regional input–output model     linear programming model    

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Arthrogryposis multiplex congenita: classification, diagnosis, perioperative care, and anesthesia

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《医学前沿（英文）》 2017年 第11卷 第1期   页码 48-52 doi: 10.1007/s11684-017-0500-4

摘要：

Arthrogryposis multiplex congenita (AMC) is a rare disorder characterized by non-progressive, multiple contractures. In addition to affected extremities, patients may also present microstomia, decreased temporomandibular joint mobility. Although the etiology of AMC is unclear, any factor that decreases fetal movement is responsible for AMC. Thus, accurate diagnosis and classification are crucial to the appropriate treatment of AMC. The development of ultrasound technology has enabled prenatal diagnosis. Very early treatment is favorable, and multidisciplinary treatment is necessary to improve the function of AMC patients. Most patients require surgery to release contracture and reconstruct joints. However, perioperative care is challenging, and difficult airway is the first concern of anesthesiologists. Postoperative pulmonary complications are common and regional anesthesia is recommended for postoperative analgesia. This review on AMC is intended for anesthesiologists. Thus, we discuss the treatment and perioperative management of patients undergoing surgery, as well as the diagnosis and classification of AMC.

关键词： arthrogryposis     amyoplasia     distal arthrogryposis     anesthesia    

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Estimation of regional physical imports and exports of EW-MFA in China using monetary input-output tables

Nan LI, Tianzhu ZHANG

《环境科学与工程前沿（英文）》 2013年 第7卷 第2期   页码 242-254 doi: 10.1007/s11783-012-0443-6

摘要： Given the statistical gaps in material flow among provinces in China, a method was introduced to estimate regional physical imports and exports (RPIE), which includes international and interregional imports/exports. This method uses provincial monetary input-output tables (MIOT) and international trade statistics. A coefficient matrix representing correlations between monetary value and physical mass for years 2000–2009 was obtained based on a detailed commodity classification and 22 material production sectors in MIOT. With the coefficient matrix as reference, RPIE was measured. Pilot calculation of both regional physical trade balance and domestic material consumption, as well as a brief analysis of these methods, were conducted using 2002 data.

关键词： economy-wide material flow accounts (EW-MFA)     monetary input-output table (MIOT)     regional physical imports and exports estimation    

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Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

《医学前沿（英文）》 2020年 第14卷 第6期   页码 792-801 doi: 10.1007/s11684-020-0745-1

摘要： Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system. Previous studies identified either regional or network alterations in patients with asthma, but inconsistent results were obtained. A key question remains unclear: are the regional and neural network deficits related or are they two independent characteristics in asthma? Answering this question is the aim of this study. By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls, brain functional measures including regional activity (amplitude of low-frequency fluctuations) and neural network function (degree centrality (DC) and functional connectivity) were calculated to systematically characterize the functional alterations. Patients exhibited regional abnormities in the left angular gyrus, right precuneus, and inferior temporal gyrus within the default mode network. Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes. Altered DC in the lingual gyrus was correlated with the degree of airway obstruction. This study elucidated different patterns of regional and network changes, thereby suggesting that the two parameters reflect different brain characteristics of asthma. These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma.

关键词： asthma     brain     regional activation     functional connectivity     resting-state fMRI    

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因地制宜推进区域能源革命的战略思考和建议

谢克昌

《中国工程科学》 2021年 第23卷 第1期   页码 1-6 doi: 10.15302/J-SSCAE-2021.01.001

摘要：

能源与经济社会、生态环境协调发展始终是我国面对的重大议题之一。虽然各地区在能源与经济社会、生态环境的协调发展上取得了一些成绩，但区域发展差异显著，区域内存在不同类型的矛盾和问题。因此，必须因地制宜推进能源革命。本文根据中国工程院重大咨询项目“推进能源生产和消费革命战略研究（三期）”主要成果，阐述了以区域能源革命为抓手协调推进能源革命与区域发展的重大意义，提出了因地制宜推进能源革命的战略思路，重点针对京津冀、长江三角洲、珠江三角洲、老工业基地（东北及山西）、中部地区、能源富集地区（新疆及能源“金三角”地区）、西南地区等区域提出了加强能源革命顶层设计，明确我国能源中长期发展战略目标和重点任务；明确区域能源革命的功能定位，形成统筹协调推进区域能源革命的良好格局；加强区域能源革命试点，通过改革办法加快探索形成推动能源革命的高效机制；明确区域能源革命实施责任和考核监督机制，确保区域能源革命取得预期效果等战略举措及对策建议。

关键词： 区域能源革命     区域发展差异     协调发展     新发展理念    

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认识北斗 建设北斗

许其凤

《中国工程科学》 2014年 第16卷 第8期   页码 26-32

摘要：

指出卫星导航系统的发展规划应与国防战略和装备能力相适应，一个包括我国周边及西太平洋的区域系统可以满足近期的军用、民用需求。分析了我国建设卫星导航系统的不利条件，并设计了规避不利条件的卫星星座。介绍了我国发展全球系统所必需的卫星对卫星观测和数据传输的技术支撑。分析了区域增强的全球系统的竞争优势。

关键词： 卫星导航系统     卫星星座设计     区域系统     区域增强    

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Local and regional contributions to PM in the Beijing 2022 Winter Olympics infrastructure areas during

《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1434-2

摘要：

• Regional transportation contributed more than local emissions during haze episodes.

关键词： 2022 Winter Olympics     PM2.5     Source apportionment    

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标题 作者 时间 类型 操作

A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

null

期刊论文

Comparative cost analysis of three different anesthesia methods in gynecological laparoscopic surgery

null

期刊论文

Effects of intracerebroventricular NMDA and non-NMDA receptor agonists or antagonists on general anesthesia

XU Aijun, TIAN Yuke, DUAN Shiming

期刊论文

民用支线飞机发展浅析

陈一坚

期刊论文

endotracheal tube with or without epidural lidocaine reduces isoflurane requirement during general anesthesia

null

期刊论文

Evaluation of ecosystem health for regional development in the southwestern Beijing, China

LIU Xuehua, ZHANG Shuang, XU Haoyang, SHAO Xiaoming

期刊论文

Understand the local and regional contributions on air pollution from the view of human health impacts

期刊论文

using the Berlin Questionnaire to detect potential high risk of adverse respiratory events in post anesthesia

null

期刊论文

Cutting CO emissions through demand side regulation: Implications from multi-regional input–output linear

期刊论文

Arthrogryposis multiplex congenita: classification, diagnosis, perioperative care, and anesthesia

null

期刊论文

Estimation of regional physical imports and exports of EW-MFA in China using monetary input-output tables

Nan LI, Tianzhu ZHANG

期刊论文

Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

期刊论文

因地制宜推进区域能源革命的战略思考和建议

谢克昌

期刊论文

认识北斗 建设北斗

许其凤

期刊论文

Local and regional contributions to PM in the Beijing 2022 Winter Olympics infrastructure areas during

期刊论文